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Muscle sarcopenia: an overview
1Department of Neurology, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue KAM 410, Los Angeles, CA 90033, USA. Smishra@hsc.usc.edu
Summary
Sarcopenia, an age-related loss of muscle mass and strength, is complex. High-resistance training (HIRT) shows promise, but further research into sarcopenia
Area of Science:
- Gerontology
- Muscle Physiology
- Metabolic Disorders
Background:
- Sarcopenia is a physiological decline in muscle mass and strength associated with aging.
- Its multifactorial etiology includes metabolic, endocrine, nutritional, mitochondrial, and genetic factors.
Purpose of the Study:
- To review current knowledge on the aetiopathogenesis of sarcopenia.
- To examine existing and potential therapeutic strategies for sarcopenia.
- To suggest future research directions for understanding muscle aging.
Main Methods:
- Literature review of sarcopenia research.
- Analysis of current treatment modalities.
- Identification of knowledge gaps in sarcopenia pathogenesis and therapy.
Main Results:
- High-resistance training (HIRT) is identified as a beneficial intervention for sarcopenia.
- Current understanding of sarcopenia pathogenesis and effective therapies remains incomplete.
- Hormone replacement therapies have shown limited benefit compared to exercise.
Conclusions:
- Sarcopenia's complex etiology necessitates a multifaceted approach to treatment and research.
- Further investigation into sarcopenia's pathogenesis is crucial for developing targeted therapies.
- Future strategies should focus on enhancing the understanding of muscle aging and potential interventions.