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Decreased apoptotic polymorphonuclear leukocyte rate in dogs with pyometra
Junichi Sano1, Keisuke Oguma, Rui Kano
1Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa 252-8510, Japan.
The Journal of Veterinary Medical Science
|February 13, 2004
Abstract:
Polymorphonuclear neutrophil (PMN) apoptosis was examined in three dogs with pyometra by TUNEL assay in a 24-hr incubation period and compared with that in healthy control dogs (n=5). The incidence of apoptotic PMNs in dogs with pyometra was 26.4 +/- 5% and that in healthy dogs was 54.3 +/- 7%. The results indicated that apoptotic PMN rates in dogs with pyometra were significantly lower than those in control dogs (p<0.05), suggesting the prolongation of PMN survival.