Related Experiment Video
Updated: May 9, 2025
Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
Published on: March 14, 2014
Widespread Majocchi's Granuloma Caused by Multidrug-Resistant Trichophyton rubrum Successfully Treated With
Utako Kimura1, Hiromitsu Noguchi2,3, Tadahiko Matsumoto2,3
1Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan.
Abstract:
We encountered a 60-year-old Japanese female patient with disseminated dermatophytosis caused by terbinafine-resistant Trichophyton rubrum with mutant SQLE (Leu393Phe substitution). Histopathology showed fungus in the dermis, indicating Majocchi granuloma. Oral fosravuconazole and topical luliconazole were administered for 18 months, resulting in invasive dermatophytosis with a high β-d-glucan level of 7320 pg/mL. The MICs of amphotericin B, posaconazole, griseofulvin, itraconazole, voriconazole, ravuconazole, and terbinafine were 0.5, 0.5, 8, 16, 8, 16, and 32 μg/mL, respectively. Amphotericin B for 6 months followed by oral posaconazole for another 6 months cured the disease. Posaconazole may be a promising agent for the treatment of multidrug-resistant dermatophytes. We present the first reported case of multiazole-resistant T. rubrum resulting from prolonged fosravuconazole treatment.
Related Concept Videos
01:23Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...