Related Experiment Videos
Lesser known aquarium fish tumor models
1Registry of Tumors in Lower Animals, Department of Pathology, George Washington University Medical Center, Washington, DC 20037, USA. patjch@gwumc.edu
Marine Biotechnology (New York, N.Y.)
|February 13, 2004
Summary
Exploring diverse fish species for cancer research reveals potential new models. Studying neoplasms in lesser-known fish offers valuable insights for comparative oncology and human cancer research.
Area of Science:
- Comparative Oncology
- Aquatic Animal Health
Background:
- Established fish models for experimental oncology are valuable but limited.
- Fish diversity suggests potential in understudied species for neoplasm research.
Purpose of the Study:
- To assess cultured fish species as surrogates for human neoplasia research.
- To identify novel fish models for studying various tumor types.
Main Methods:
- Reviewed the Registry of Tumors in Lower Animals database.
- Conducted a literature search for spontaneous and induced fish neoplasms.
Main Results:
- Identified neoplasms in over 215 fish species across 69 families.
- Highlighted prominent families: Poeciliidae, Cyprinidae, Cichlidae, and Salmonidae.
- Noted potential models: bladder tumors in Oscar, osteogenic tumors in coho salmon, and nephroblastoma in Japanese eels.
Conclusions:
- Lesser-known fish species can serve as valuable models for specific human neoplasia.
- Further investigation into these diverse fish models can advance comparative oncology.
- Expanding the range of fish models enhances research capabilities in cancer studies.