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Mitral regurgitation disappearance after cibenzoline treatment in a patient with hypertrophic obstructive

Keiichi Inada1, Kimiaki Komukai, Chikara Mori

  • 1Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo.

Internal Medicine (Tokyo, Japan)
|February 18, 2004
PubMed

Insights

Cibenzoline effectively reduced the left ventricular outflow pressure gradient (LVPG) in a patient with hypertrophic obstructive cardiomyopathy (HOCM). This treatment also significantly improved associated mitral regurgitation (MR).

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is frequently associated with mitral regurgitation (MR).
  • Left ventricular outflow pressure gradient (LVPG) is a key characteristic of HOCM.

Observation:

  • A 62-year-old female patient with HOCM and severe MR presented with significant LVPG (118 mmHg).
  • Echocardiography revealed asymmetrical septal hypertrophy and systolic anterior movement of the mitral valve.

Findings:

  • Intravenous cibenzoline administration (70 mg) dramatically decreased LVPG from 110 mmHg to 16 mmHg.
  • Post-injection left ventriculography showed resolution of MR, indicating cibenzoline's efficacy.

Implications:

  • Cibenzoline demonstrates potential as a therapeutic agent for managing LVPG in HOCM.
  • The drug may also resolve MR secondary to the pressure gradient in HOCM patients.

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