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5-ht6 receptors.

Marie L Woolley1, Charles A Marsden, Kevin C F Fone

  • 1Institute of Neuroscience, School of Biomedical Science, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

Current Drug Targets. CNS and Neurological Disorders
|February 18, 2004
PubMed
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The 5-hydroxytryptamine(6) (5-HT6) receptor, a key CNS target, regulates cognition and mood. Research highlights its role in neurological functions, supporting its formal recognition.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • The 5-hydroxytryptamine(6) (5-HT6) receptor is a recent addition to the 5-HT receptor family.
  • Selective antagonists for the 5-HT6 receptor have been developed, revealing its potential functional roles.
  • High affinity of psychiatric drugs and CNS-exclusive expression stimulate research interest.

Purpose of the Study:

  • To review the discovery, genetics, distribution, pharmacology, and function of the 5-HT6 receptor.
  • To highlight the growing body of evidence regarding the 5-HT6 receptor's functions.
  • To advocate for the formal recognition and uppercase nomenclature of the 5-HT6 receptor.

Main Methods:

  • Comprehensive literature review of existing research on the 5-HT6 receptor.

Related Experiment Videos

  • Analysis of pharmacological data, including drug affinities.
  • Examination of genetic and distribution studies within the central nervous system.

    • Main Results:

    • The 5-HT6 receptor is predominantly expressed in the CNS, particularly in limbic and cortical regions.
    • It appears to modulate glutamatergic and cholinergic neuronal activity.
    • Evidence links the 5-HT6 receptor to the regulation of cognition, feeding, affective state, and seizures.

    Conclusions:

    • The 5-HT6 receptor plays a significant role in central nervous system functions.
    • The extensive research and identified functions support formal recognition of the 5-HT6 receptor.
    • Uppercase nomenclature is proposed for the 5-HT6 receptor to reflect its established status.