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Synthetic approaches to the 2002 new drugs
1Pfizer Global Research and Development, Pfizer Inc., Groton CT 06340, USA. jin_li@groton.pfizer.com
Mini Reviews in Medicinal Chemistry
|February 18, 2004
Abstract:
New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. In addition, these new chemical entities (NCEs) not only provide insights into molecular recognition, but also serve as drug-like leads for designing future new drugs. Therefore, it is important to be acquainted with these new structures as well as their syntheses. To these ends, this review covers the syntheses of 28 NCEs marketed in 2002.