Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene expression in aggressive fibromatosis.

Keith M Skubitz1, Amy P N Skubitz

  • 1Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.

The Journal of Laboratory and Clinical Medicine
|February 18, 2004
PubMed
Summary

Gene expression profiling identified specific genes overexpressed in aggressive fibromatosis. These molecular patterns may help classify aggressive fibromatosis subtypes for clinical significance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein Enrichment from Ascites Fluid Using Nanotrap Hydrogel Particle Technology.

Journal of proteome research·2026
Same author

Repurposing the liquid-based Pap test for the detection of ovarian cancer protein biomarkers.

Clinical proteomics·2026
Same author

Evolution of CEACAM1 N Domain Biologically Active Sites in Primates.

Biology·2025
Same author

5-fluoro-deoxyglucose PET/CT response after neoadjuvant chemotherapy predicts long-term outcomes in soft tissue sarcomas: Results from a prospective trial.

Cancer·2025
Same author

A Peptide Derived from Nectin-4 Increases Cisplatin Cytotoxicity in Cell Lines and Cells from Ovarian Cancer Patients' Ascites.

Cancers·2025
Same author

Clinical Benefit of Pegylated Liposomal Doxorubicin and High Prevalence of Pre-Existing Psychiatric Conditions in Patients with Desmoid-Type Fibromatosis.

Cancers·2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Aggressive fibromatosis exhibits diverse biological behaviors.
  • Understanding the molecular underpinnings of aggressive fibromatosis is crucial for classification.

Purpose of the Study:

  • To identify genes differentially expressed in aggressive fibromatosis compared to normal tissues.
  • To explore the potential of gene expression patterns for classifying fibromatosis subtypes.

Main Methods:

  • Gene expression analysis using Affymetrix GeneChip U_133 arrays on 12 aggressive fibromatosis samples and normal tissues.
  • Quantification of gene expression differences via fold change analysis.
  • Eisen clustering to identify molecular subgroups within aggressive fibromatosis.

Main Results:

  • Identified a set of genes significantly overexpressed in aggressive fibromatosis versus normal skeletal muscle.
  • ADAM12, WISP-1, SOX-11, and fibroblast activation protein-alpha were uniquely overexpressed.
  • Discovered two distinct subgroups of aggressive fibromatosis based on gene expression profiles.

Conclusions:

  • Gene expression patterns offer a potential tool for classifying aggressive fibromatosis subtypes.
  • Such molecular classification may have significant clinical implications for patient management.

Related Experiment Videos