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[HPLC fingerprint of the tablets of Ginkgo biloba L]
Ya-ping Xu1, Tong-wei Yao, Jun-wei Jiang
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031 China.
Objective:
To establish the method for determination of the fingerprint of tablets of Ginkgo biloba L.
Methods:
HPLC-DAD was used to determine the constituents in tablets. Diamonsil C18(200 mm x 4.6 mm, 5 microm) was used as analysis column and acetonitrile/KH(2)PO(4) as mobile phase with gradient elution. The column temperature was at 24 degree. The profile of chemical constituents in control sample and tablets obtained from the chromatograms were analyzed by similarity software.
Result:
The method developed for components analysis of the standard extracts was linear within certain concentration (r>0.999). There was no difference between the fingerprints of 3 batches of products. The fingerprints of tablets and the extract showed a good similarity(>0.965).
Conclusion:
This method is accurate simple and can be used for the quality control of Ginkgo biloba L. preparations.
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