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Updated: Aug 26, 2026

Synthesis, Hemoglobin Encapsulation and Biorthogonal PEGylation in Hierarchically Porous UiO-66 Nanoparticles for Oxygen Delivery Applications
Published on: May 8, 2026
Heparin coated poly(alkylcyanoacrylate) nanoparticles coupled to hemoglobin: a new oxygen carrier
Cedric Chauvierre1, M C Michael C Marden, Christine Vauthier
1Laboratoire de Physico-Chimie, Faculté de Pharmacie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Université Paris-Sud XI, 5 rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
Abstract:
A new generation of drug delivery systems based on heparin-poly(isobutylcyanoacrylate) copolymers has been developed to carry hemoglobin. These copolymers spontaneously form, in water, nanoparticles with a ciliated surface of heparin. These nanoparticles maintain the heparin antithrombotic properties and inhibit complement activation. One ml of nanoparticle suspension can be loaded with up to 2.1mg of hemoglobin, which preserves its ligand binding capacity. This work constitutes the first demonstration of hemoglobin loaded on nanoparticle surface, rather than being encapsulated. With a size of 100 nm, these drug delivery systems make suitable tools in the treatment of thrombosis oxygen deprived pathologies.
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