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Related Experiment Videos

[Vitamins during high dose chemo- and radiotherapy].

M R Clemens1, C I Müller-Ladner, K F Gey

  • 1Eberhard-Karls-Universität Tübingen, Medizinische Klinik und Poliklinik, Abteilung Innere Medizin II, Bundesrepublik Deutschland.

Zeitschrift Fur Ernahrungswissenschaft
|June 1, 1992
PubMed
Summary

Chemotherapy and radiation for bone marrow transplant deplete key vitamins like alpha-tocopherol (vitamin E) and beta-carotene (provitamin A). This study suggests high-dose antioxidants may reduce treatment toxicity.

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Area of Science:

  • Biochemistry
  • Oncology
  • Nutrition Science

Background:

  • Bone marrow transplantation (BMT) conditioning therapy, often including chemotherapy and total body irradiation (TBI), can induce oxidative stress.
  • Vitamins A and E, along with carotenoids, are crucial antioxidants that may be depleted during intensive cancer treatments.

Purpose of the Study:

  • To assess the impact of conditioning chemotherapy (with or without TBI) on plasma and red blood cell membrane concentrations of key vitamins and antioxidants.
  • To explore the potential role of lipid-soluble antioxidant depletion in treatment-related toxicity.

Main Methods:

  • Plasma levels of alpha-tocopherol, gamma-tocopherol, beta-carotene, lycopene, retinol, and ascorbic acid were measured in 22 BMT patients before, during, and after conditioning therapy.
  • Alpha-tocopherol was also quantified in red blood cell membranes.

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  • Vitamin doses were administered to maintain baseline levels for retinol and ascorbic acid.

    • Main Results:

    • Plasma concentrations of alpha-tocopherol (vitamin E) and beta-carotene (provitamin A) significantly decreased (20% and 50%, respectively) after conditioning therapy.
    • Retinol (vitamin A) and ascorbic acid (vitamin C) levels were maintained due to sufficient administered doses.
    • The observed loss of lipid-soluble antioxidants suggests increased lipid peroxidation during intensive therapy.

    Conclusions:

    • Conditioning chemotherapy for BMT leads to a significant reduction in essential lipid-soluble antioxidants, vitamin E and beta-carotene.
    • This depletion may be linked to increased oxidative stress and lipid peroxidation.
    • Further intervention studies with high-dose antioxidants are warranted to mitigate treatment-related toxicity, particularly in the liver and lungs.