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Updated: Aug 26, 2026

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses
Published on: June 8, 2022
Some pyridazinone and phthalazinone derivatives and their vasodilator activities
Seref Demirayak1, Ahmet Cagri Karaburun, Ismail Kayagil
1Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu, Eskisehir, Turkey. sdemiray@anadolu.edu.tr
Abstract:
In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4-aminophenyl)-1(2H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.
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