Early prenatal MR imaging diagnosis of polymicrogyria
Andrea Righini1, Salvatore Zirpoli, Federica Mrakic
1Department of Radiology and Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy.
Abstract:
The case of a 24-week-old fetus that showed features suggestive of focal cortical developmental anomaly at prenatal MR imaging is presented. The anomaly was confirmed to be polymicrogyria by 34-week prenatal and the 3-day postnatal MR imaging studies. The report demonstrates that the development of polymicrogyria can be assessed throughout different stages by prenatal MR imaging. In the case reported, the additional presence of periventricular heterotopia strongly suggests that a neuronal migration alteration coexisted with a postmigrational disorder.
Insights
Prenatal MRI can assess fetal polymicrogyria development. This case highlights its detection and co-occurring neuronal migration disorders in utero.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Imaging
Background:
- Focal cortical developmental anomalies present diagnostic challenges.
- Polymicrogyria is a congenital brain malformation characterized by excessive small gyri.
- Prenatal diagnosis of central nervous system anomalies is crucial for management.
Purpose of the Study:
- To present a case of fetal polymicrogyria diagnosed via prenatal magnetic resonance (MR) imaging.
- To demonstrate the utility of serial prenatal MR imaging in assessing the developmental progression of polymicrogyria.
- To explore the potential coexistence of neuronal migration disorders with polymicrogyria.
Main Methods:
- Case report of a 24-week-old fetus with suspected focal cortical developmental anomaly on prenatal MR imaging.
- Serial MR imaging performed at 34 weeks gestation and 3 days postpartum for confirmation and assessment.
- Review of imaging findings to identify features of polymicrogyria and associated abnormalities.
Main Results:
- Prenatal MR imaging at 24 weeks suggested a focal cortical developmental anomaly.
- Confirmation of polymicrogyria at 34 weeks gestation and in the neonatal period via MR imaging.
- Identification of periventricular heterotopia, indicating a coexisting neuronal migration disorder.
Conclusions:
- Prenatal MR imaging is effective for assessing the development of polymicrogyria across gestational stages.
- The case suggests that neuronal migration alterations can coexist with postmigrational disorders like polymicrogyria.
- Serial imaging aids in understanding the progression and associated pathologies of congenital brain malformations.
