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[Pharmacokinetics of honokiol in rats]
Shi-Zhong Chen1, Hui Jia, Yao-Hua Wu
1Laboratory of Traditional Chinese Medicine, Peking University School of Pharmaceutical Sciences, Beijing 100083, China. chenshizhong@vip.sina.com
Objective:
To investigate the pharmacokinetics of honokiol in rats.
Methods:
Honokiol injection was delivered by vein injection to SD-rats. The blood samples were gathered at a series of time lags. Honokiol in rat plasma was determined with an RP-HPLC method and the data were analyzed with program 3P87.
Results:
After i.v. injection of honokiol, concentration-time curves were fitted to a 3-compartment model: with halftime of 2.8 min, 11.9 min, and 56.8 min.
Conclusion:
Honokiol was quickly distributed in rats after i.v. and the concentration decreased rapidly. Our studies provided important referrence to the research on the pharmacodynamics and the pharmaceutics of Honokiol.
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