[Human telomerase P53 estrogen and progesterone receptor expression in endometrial carcinoma]

To study the role of hTERT and c-myc,P53,ER,PR in endometrial carcinoma carcinogenesis.

The expression of hTERT, c-myc mRNA, P53 protein, ER and PR examined by in situ hybridization and immunohistochemistry in 14 cases of endometrial simple hyperplasia, 10 of complex hyperplasia, 8 of atypical hyperplasia and 52 with endometrial carcinoma.

(1) The positive rate of hTERT in simple, complex, atypical hyperplasia and carcinoma were 14.3% (2/14), 50.0% (4/8), 80.0% (8/10) and 92.3% (48/52), respectively. The prevalence and intensity of hTERT signal were greater in the carcinomas and atypical hyperplasia than those in simple or complex hyperplasia (P<0.05). The expressions of c-myc and P53 were similar to that of hTERT. (2) The expressions of hTERT, c-myc, P53 and PR were significantly correlated with tumor differentiation. The expressions of c-myc and P53 in type I were significantly different from those in type II. The expression of c-myc with lymph node metastasis was significantly higher than that without metastasis. (3) The positive correlation between hTERT and c-myc was found in endometrial carcinoma (r=0.398 8, P<0.05); It was also found between hTERT and P53 in type II endometrial carcinoma (r=1.000, P<0.05).

The expressions of hTERT, c-myc and P53 may be involved in the progression from the endometrial atypical hyperplasia to cancer. They may also be associated with the prognosis of endometrial carcinoma. c-myc and P53 may play a role in the transcriptive activation of hTERT gene in endometrial carcinoma.