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In Vitro Scratch Assay to Demonstrate Effects of Arsenic on Skin Cell Migration
Published on: February 23, 2019
Molecular mechanisms of arsenic carcinogenesis
Chuanshu Huang1, Qingdong Ke, Max Costa
1Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA. chuanshu@env.med.nyu.edu
Abstract:
Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.
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