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Updated: Aug 26, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided
Jeffrey H Toney1, Sonia Navas-Martín, Susan R Weiss
1Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Upper Montclair, New Jersey 07043, USA. toneyje@mail.montclair.edu
Abstract:
A novel human coronavirus has been reported to be the causative agent of severe acute respiratory syndrome (SARS). Since replication of HcoVs depends on extensive proteolytic processing, the main proteinase, 3CLpro, is an attractive drug target for anti-SARS agents. We have employed molecular docking of a chemical database into the active site of 3CLpro to search for non-peptidyl inhibitors. One compound was identified to be the natural product sabadinine, isolated from a historical herbal remedy.
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