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Cutaneous reactions to granulocyte-monocyte colony-stimulating factor
D R Mehregan1, A F Fransway, J H Edmonson
1Department of Dermatology, Mayo Clinic, Rochester, Minn. 55905.
Archives of Dermatology
|August 1, 1992
Summary
Granulocyte-monocyte colony-stimulating factor (GMCSF) causes skin reactions in patients. Eosinophils may play a role in these reactions due to GMCSF stimulation.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Granulocyte-monocyte colony-stimulating factor (GMCSF) is a hematopoietic growth factor.
- GMCSF stimulates neutrophil, eosinophil, and monocyte proliferation and differentiation.
- Cutaneous reactions are a known side effect of GMCSF therapy.
Purpose of the Study:
- To review and characterize the cutaneous reactions associated with GMCSF administration.
- To investigate the potential role of eosinophils in GMCSF-induced skin reactions.
Main Methods:
- Retrospective review of 26 patients receiving GMCSF chemotherapy.
- Clinical observation of cutaneous reactions.
- Histopathological examination of skin biopsy specimens from four patients.
Main Results:
- 21 out of 26 patients developed generalized cutaneous reactions.
- Histopathology revealed perivascular and periadnexal lymphocytic inflammation and eosinophilia.
- Eosinophil infiltration and extracellular deposition of major basic protein were observed in biopsy specimens.
Conclusions:
- Cutaneous reactions are common during GMCSF administration.
- Eosinophils, activated by GMCSF, may contribute to the pathogenesis of these skin reactions.