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Quantitative perfusion map of malignant liver tumors, created from dynamic computed tomography data
Yoshito Tsushima1, Shintaro Funabasama, Jun Aoki
1Department of Radiology, Motojima General Hospital, 3-8 Nishi-Honcho, Ohta, Gunma 373-0033, Japan.
Academic Radiology
|February 21, 2004
Summary
Perfusion computed tomography (CT) offers quantitative insights into liver tumor perfusion. This technique aids in evaluating tumor angiogenesis and monitoring treatment response.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Malignant liver tumors exhibit diverse vascular patterns.
- Accurate assessment of tumor vascularity is crucial for diagnosis and treatment planning.
Purpose of the Study:
- To evaluate the utility of perfusion computed tomography (CT) in characterizing variable malignant liver tumors.
- To define the role of quantitative color mapping in assessing liver tumor perfusion.
Main Methods:
- Perfusion CT was performed on 28 patients with 36 malignant liver tumors.
- Quantitative maps of arterial and portal perfusion were generated using the maximum slope method.
- Perfusion CT was assessed before and after transcatheter arterial chemoembolization in four patients.
Main Results:
- Liver tumors appeared hypervascular on arterial perfusion CT.
- Hepatocellular carcinomas showed significantly higher arterial perfusion (0.94 mL/min/mL) than colorectal carcinomas (0.67 mL/min/mL).
- Transcatheter arterial chemoembolization led to decreased arterial perfusion; portal perfusion was absent in most tumors.
Conclusions:
- Perfusion CT provides quantitative data on liver tumor arterial and portal perfusion.
- This technique can assess tumor angiogenesis, detect perfusion changes, and monitor therapeutic response.
- Perfusion CT offers combined functional and anatomical information for liver tumor evaluation.