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Related Experiment Videos

Genetic analysis of maximum cigarette-use phenotypes.

Nancy L Saccone1, Rosalind J Neuman, Scott F Saccone

  • 1Department of Genetics, Washington University School of Medicine, St, Louis, Missouri, USA. nlims@vodka.wustl.edu

BMC Genetics
|February 21, 2004
PubMed
Summary

This study analyzed maximum cigarette use (MAXCIG) in smokers using Framingham Heart Study data. Linkage analysis revealed modest evidence on several chromosomes, highlighting the importance of handling non-smokers in genetic studies.

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Area of Science:

  • Genetics
  • Epidemiology
  • Behavioral Science

Background:

  • Utilized Framingham Heart Study data for Genetic Analysis Workshop 13.
  • Defined cigarette-use phenotype M based on maximum cigarettes-per-day (MAXCIG).

Purpose of the Study:

  • To perform sib-pair based linkage analysis for cigarette-use phenotype M.
  • To investigate genetic linkage related to smoking behavior.

Main Methods:

  • Defined phenotype M using maximum cigarettes-per-day (MAXCIG).
  • Adjusted for covariates: gender and year of birth.
  • Performed sib-pair based linkage analysis.

Main Results:

  • Primary analyses (excluding individuals with MAXCIG = 0) showed modest linkage evidence.

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  • LOD scores over 1 were observed on chromosomes 5, 9, 13, 14, and 22.

    • Conclusions:

    • Results do not provide definitive linkage evidence to specific chromosomal regions.
    • Handling of individuals with MAXCIG = 0 (substance-naive) significantly impacts linkage results.
    • Future studies should include direct assessments of maximum and quantitative cigarette use.