Related Experiment Video
Updated: Jan 10, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
Alcohol-Related Liver Disease: Spectrum of Disease, Natural History, and Outcomes
Jessica A Musto1, John P Rice1
1Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Abstract:
Alcohol-related liver disease (ALD) is a common cause of liver-related mortality and a leading indication for transplantation. On histopathology, bland steatosis is generally nonprogressive while steatohepatitis can lead to progressive fibrosis and eventually cirrhosis. Symptoms of ALD are minimal until the development of cirrhosis or alcohol-related hepatitis. Noninvasive testing can stage asymptomatic ALD and estimate prognosis. Alcohol abstinence remains the cornerstone of treatment of ALD. Treating comorbid liver diseases such as viral hepatitis or metabolic risk factors are also important to prevent ALD progression.
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