Related Experiment Video
Updated: Aug 26, 2026
Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Comparative testing of 5 nicotine systems: initial use and preferences
Nina G Schneider1, Richard E Olmstead, Mitchell Nides
1Nicotine Dependence Research Unit, Greater Los Angeles Veterans Administration, West Los Angeles, CA 90073, USA. ngs@ucla.edu
Objective:
To test initial reactions to 5 nicotine treatments (NRTs: 2 and 4 mg gum, inhaler, nasal spray, tablet) in a crossover study (n=41).
Methods:
Subjects used each medication on arising (1/2 day) and resumed smoking each afternoon. Subjects rated (individually) and ranked (comparatively) treatments on use, reinforcement, withdrawal, craving, and preferences.
Results:
Overall preferences: inhaler (49%), 4 mg gum (24%), 2 mg gum (10%), 2 mg tablet (10%), nasal spray (7%). Overall results were consistent with ratings and rankings of individual characteristics of drugs.
Conclusion:
Subjects had varied reactions to NRTs that may affect initiation of cessation.
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