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Related Experiment Videos

Cytokines and fever.

Bruno Conti1, Iustin Tabarean, Cristina Andrei

  • 1Harold L. Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|February 24, 2004
PubMed
Summary

Cytokines, like interleukin-1 (IL-1) and interleukin-6 (IL-6), influence fever by acting as pyrogens or antipyretics. Their communication between immune and nervous systems is key to thermoregulation.

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Area of Science:

  • Neuroimmunology
  • Physiology

Background:

  • Cytokines are crucial for intercellular communication in nervous and immune systems.
  • Fever is regulated by hypothalamic thermoregulatory mechanisms.
  • Cytokines link the immune and central nervous systems, influencing fever.

Purpose of the Study:

  • To explore the role of cytokines in modulating fever responses.
  • To investigate the central actions of cytokines on thermoregulation.

Main Methods:

  • Analyzing serum and cerebrospinal fluid (CSF) cytokine levels during fever.
  • Detecting cytokine receptors on brain cells and observing effects of cytokine administration/neutralization.
  • Utilizing cytokine and cytokine receptor transgenic models to study fever.

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Main Results:

  • Proinflammatory cytokines (IL-1, IL-6, TNF) and anti-inflammatory cytokines (IL-1ra, IL-10) are key players.
  • Peripheral cytokines can signal the brain via neuronal pathways or crossing the blood-brain barrier.
  • Mechanisms of cytokine action on hypothalamic thermoregulatory neurons are not fully understood.

Conclusions:

  • Cytokines significantly modulate fever responses through central and peripheral actions.
  • Further research is needed to fully elucidate the mechanisms of cytokine-induced thermoregulation.