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Updated: Aug 26, 2026

Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
Published on: February 12, 2020
Design and sample characteristics of the PRISM-E multisite randomized trial to improve behavioral health care for the
Sue E Levkoff1, Hongtu Chen, Eugenie Coakley
1Brigham and Women's Hospital, Harvard Medical School, USA.
Objective:
To describe the design of the Primary Care Research in Substance Abuse and Mental Health for Elderly (PRISM-E) study and baseline characteristics of the randomized primary care patients with mental health problems and at-risk alcohol use.
Method:
Adults aged 65 and older were screened at primary care clinics from 10 study sites throughout the United States. Those diagnosed for depression, anxiety, and/or at-risk alcohol consumption were randomized to either integrated or enhanced referral care.
Results:
Of the 23,828 participants, 14% had a positive assessment for depressive and/or anxiety disorders, and 6% had at-risk alcohol consumption diagnoses. Among patients with mental health diagnoses, there was a higher preponderance of younger ages, women, and ethnic minorities. Among patients with at-risk drinking, there was a higher preponderance of younger ages, Whites, and men.
Discussion:
These findings indicate the need for screening in primary care and for engaging older adults in treatment.