Coagulation defects in trauma patients: etiology, recognition, and therapy
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Updated: Aug 26, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
1Division of Medical Oncology, L586 Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. delought@ohsu.edu
Abstract:
Trauma patients have many reasons to have defects in coagulation. These can be caused by the trauma or because of pre-existing disorders. Trauma patients who are at risk for coagulation defects should be screened with the basic tests (aPTT, INR/PT, platelet counts, hematocrit, and fibrinogen), with therapy based on the results. Attention also should be paid to any other correctable factors such as hypothermia. Finally, pre-existing disorders can influence the patient's hemostasis greatly and may require specific therapies.
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