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Updated: Jul 27, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
Published on: January 30, 2014
Third and fourth branchial pouch anomalies
P A Rea1, B E J Hartley, C M Bailey
1Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London, UK. peter@rea999.freeserve.co.uk
Abstract:
Congenital sinuses arising from the pyriform fossae are rare. They may present as neck cysts, recurrent neck abscesses, thyroiditis or neonatal stridor. Children typically undergo multiple surgical procedures before the diagnosis is made. We present our recent experience of five third-pouch sinuses and four fourth-pouch sinuses, including one bilateral case. The median age at presentation was four years. The mean number of operations prior to diagnosis was six (range 0-13), with a mean delay to diagnosis of six years. The diagnosis was made by barium swallow, by ultrasound, at pharyngoscopy or at open surgery. The median age at definitive surgery was 10 years. Definitive treatment involved complete excision of the sinus and neck mass in seven cases. Two sinuses were treated with endoscopic diathermy to their internal opening. Adoption of the correct nomenclature, diagnostic tools and operative requirements for these cases will help reduce the significant morbidity.
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