Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microarray analysis of interferon-regulated genes in SLE.

Mary K Crow1, Kyriakos A Kirou, Jay Wohlgemuth

  • 1Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY, USA. crowm@hss.edu

Autoimmunity
|February 27, 2004
PubMed
Summary

Systemic lupus erythematosus (SLE) shows significantly overexpressed interferon-regulated genes in immune cells. This suggests a key role for interferons (IFNs) in SLE pathogenesis and potential new therapeutic targets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An NT5E loss-of-function variant permits tissue inflammation and hypertension in systemic lupus erythematosus.

iScience·2026
Same author

Whole blood transcriptome profiling in patients treated with deucravacitinib and novel mechanistic insights into TYK2 inhibition in lupus: results from a post hoc analysis of the PAISLEY SLE phase 2 trial.

Annals of the rheumatic diseases·2026
Same author

Perioperative Management Considerations for Patients with Systemic Lupus Erythematosus.

Current rheumatology reports·2026
Same author

Chasing the target: reports from the Advances in Targeted Therapies meeting, 2025.

Annals of the rheumatic diseases·2026
Same author

New developments and future directions in the management of systemic lupus erythematosus.

Current opinion in immunology·2026
Same author

Renal Replacement Therapy in Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review and Meta-Analysis.

ACR open rheumatology·2025

Area of Science:

  • Immunology
  • Genetics

Background:

  • Interferon-alpha (IFNalpha) dysregulation in systemic lupus erythematosus (SLE) has been known for decades.
  • Recent research highlights the critical role of the interferon cytokine family in SLE.
  • IFN-regulated genes are significantly overexpressed in SLE mononuclear cells.

Purpose of the Study:

  • To investigate the role of interferon-regulated genes in SLE.
  • To understand the contribution of IFNs to immune system alterations in SLE.
  • To identify potential therapeutic targets for SLE.

Main Methods:

  • Large-scale microarray technology was used to analyze global gene expression.
  • Gene expression patterns were studied in peripheral blood cells from SLE patients and control subjects.

Related Experiment Videos

Main Results:

  • IFN-regulated genes were found to be significantly overexpressed in SLE mononuclear cells.
  • This overexpression suggests a substantial contribution of IFNs to the immune system alterations characteristic of SLE.

Conclusions:

  • Increased interferon activity may explain many immune system alterations and autoimmunity in SLE.
  • Further research is needed to identify the specific IFNs driving this gene expression signature.
  • Understanding these factors could lead to novel targeted therapies for SLE.