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Blood component processing technique and plasma quality
A M Suontaka1, K Bremme, O Akerblom
1Department of Immunology, Karolinska Hospital, Stockholm, Sweden.
Infusionstherapie Und Transfusionsmedizin
|June 1, 1992
Summary
This study demonstrates that a triple blood bag system effectively separates blood components, reducing costs. While minor increases in certain factors were observed, they are clinically insignificant, making it a viable alternative to quadruple systems.
Area of Science:
- Blood banking and transfusion medicine
- Biochemistry
- Hematology
Background:
- Maintaining closed systems for blood component preparation is crucial.
- Quadruple blood bag systems are commonly used for buffy coat removal.
- Cost-effectiveness in blood banking is an ongoing concern.
Purpose of the Study:
- To evaluate the feasibility of a triple blood bag system as a cost-effective alternative to quadruple systems.
- To assess the impact of a triple bag system on key biochemical markers in blood components.
Main Methods:
- Blood components were separated using a triple bag system after centrifugation.
- Plasma was transferred to satellite bags and stored at 4°C for 14 days.
- Levels of platelet factor 4, elastase activity, C1-esterase inhibitor, and other markers were measured.
Main Results:
- A statistically significant increase in platelet factor 4 and elastase activity was observed.
- No significant changes were found in C1-esterase inhibitor, kallikrein inhibiting activity, thrombin-antithrombin complexes, soluble fibrin, fibrinopeptide A, or proteolytic activity.
- Platelet counts met the criteria for platelet-poor plasma.
Conclusions:
- The triple blood bag system is a clinically insignificant and cost-effective alternative to the quadruple system.
- This technique allows for the reduction of the CPD/additive solution 4-pack blood bag system to a less expensive 3-pack system.
- The observed biochemical changes do not compromise the clinical utility of the separated blood components.