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Terlipressin bolus induces systemic vasoconstriction in septic shock
Mark J Peters1, Rachelle A Booth, Andy J Petros
1Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Objective:
To report the use of a synthetic, long-acting, vasopressin analog, terlipressin, as an effective vasoconstrictor in septic shock.
Design:
Case report.
Setting:
A 22-bed pediatric intensive care unit in a tertiary referral center.
Patient:
An 11-yr-old male with multiple-organism Gram-negative septic shock with high normal cardiac output as assessed by pulse contour analysis and low systemic vascular resistance despite norepinephrine infusion.
Intervention:
Two peripherally administered doses of terlipressin (0.5 mg).
Measurements And Main Results:
Each dose of terlipressin was associated with a rapid increase in systemic vascular resistance, despite weaning and discontinuation of norepinephrine infusion from 0.15 microg.kg(-1).min(-1) lasting approximately 6 hrs.
Conclusion:
Terlipressin may be useful for sepsis-induced vasodilation.