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[Decreased bone mineral density in HIV-infected children receiving highly active antiretroviral therapy]

P Rojo Conejo1, J T Ramos Amador, L García Piñar

  • 1Unidad de Inmunodeficiencias, Departamento de Pediatría, Hospital 12 de Octubre, Madrid, España. pablorojoconejo@netscape.net

Anales De Pediatria (Barcelona, Spain : 2003)
|February 28, 2004
PubMed

Insights

A high prevalence of decreased bone mineral density was observed in HIV-infected children on highly active antiretroviral therapy (HAART). Further research is needed to understand the causes and associated factors of these bone alterations.

Area of Science:

  • Pediatric infectious diseases
  • Bone metabolism and endocrinology
  • HIV/AIDS management

Context:

  • Highly active antiretroviral therapy (HAART) has improved outcomes for children with HIV.
  • However, concerns exist regarding potential long-term metabolic and bone health complications.
  • This study investigates bone health in a pediatric HIV cohort on HAART.

Purpose:

  • To determine the prevalence of bone mineral density (BMD) alterations in HIV-infected children receiving HAART.
  • To identify potential factors associated with decreased BMD in this population.
  • To assess the rates of osteopenia and osteoporosis in the studied cohort.

Summary:

  • Bone dual energy X-ray absorptiometry (DEXA) was conducted on 50 HIV-infected children on HAART.
  • Forty percent exhibited reduced BMD, with 36% diagnosed with osteopenia and 4% with osteoporosis.
  • No significant associations were found between decreased BMD and analyzed factors.

Impact:

  • Highlights a significant prevalence of decreased bone mineral density in pediatric HIV patients on HAART.
  • Underscores the need for further investigation into the etiology and risk factors for these bone abnormalities.
  • Informs clinical monitoring and management strategies for HIV-infected children undergoing long-term HAART.
Abstract

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