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Bone marrow toxicity after yellow phosphorus ingestion
A J Tafur1, J A Zapatier, L A Idrovo
1Toxicology Service, Luis Vernaza Hospital, Guayaquil, Ecuador.
Emergency Medicine Journal : EMJ
|February 28, 2004
Summary
Yellow phosphorus in fireworks can be dangerous when ingested. A case study shows a teenager recovered within 48 hours after ingesting fireworks, despite initial bone marrow changes.
Area of Science:
- Toxicology
- Hematology
- Case Study
Background:
- Fireworks containing yellow phosphorus are frequently ingested during holidays, posing a significant public health risk.
- Yellow phosphorus poisoning can lead to severe systemic effects, requiring prompt medical attention.
Observation:
- A 17-year-old female presented with isolated upper abdominal pain after intentionally ingesting approximately 5.5 mg of yellow phosphorus.
- Physical examination revealed no abnormalities.
- Initial blood tests indicated a notable decrease in granulocyte count.
Findings:
- Bone marrow biopsy demonstrated reduced cellularity and degenerative changes, suggesting toxicity.
- The patient experienced spontaneous remission within 48 hours without further medical intervention or persistent symptoms.
Implications:
- This case highlights the potential for severe hematological toxicity from yellow phosphorus ingestion.
- It also suggests that even significant ingestions may lead to spontaneous recovery in some cases.
- Further research is needed to understand the full spectrum of yellow phosphorus toxicity and recovery patterns.