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Related Experiment Videos

The number of retrieved oocytes does not decrease during consecutive gonadotrophin-stimulated IVF cycles.

Evelien J de Boer1, Isolde Den Tonkelaar, Curt W Burger

  • 1Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam.

Human Reproduction (Oxford, England)
|March 3, 2004
PubMed
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The number of retrieved oocytes does not decrease over multiple in vitro fertilization (IVF) cycles when accounting for factors like age and treatment variations. Age is the primary factor influencing oocyte yield in women undergoing repeated IVF.

Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization (IVF) Research
  • Clinical Embryology

Background:

  • Investigating trends in oocyte retrieval is crucial for optimizing IVF success rates.
  • Previous studies have not conclusively determined if oocyte yield declines with consecutive IVF cycles.
  • Understanding factors influencing oocyte quantity is vital for patient counseling and treatment protocols.

Purpose of the Study:

  • To determine if there is a decreasing trend in the number of retrieved oocytes in women undergoing at least seven consecutive IVF cycles.
  • To analyze the impact of age, gonadotropin dosage, stimulation protocols, and treatment year on oocyte yield over time.
  • To provide evidence-based insights into the long-term outcomes of repeated IVF attempts.

Main Methods:

Related Experiment Videos

  • A nationwide retrospective cohort study of 330 women undergoing at least seven consecutive IVF cycles in the Netherlands (1983-1995).
  • Poisson regression analysis was employed to assess trends in oocyte retrieval across the first six IVF cycles.
  • Adjustments were made for age, gonadotropin dosage, stimulation protocols (fertility drug and GnRH agonist use), and treatment year.

    • Main Results:

    • Unadjusted analysis showed a non-significant decrease in oocytes retrieved (-0.06 in cycle 6 vs. cycle 1).
    • Adjusting for treatment variables revealed a significant decrease (-0.19 oocytes), but this was largely negated when age was included (-0.05 oocytes).
    • The results indicate that age is a significant confounding factor in the perceived decline of oocyte yield over successive IVF cycles.

    Conclusions:

    • There is no significant decrease in retrieved oocytes over consecutive IVF cycles when controlling for age, treatment variations, and year of treatment.
    • Increasing female age is the primary driver for any observed decrease in oocyte yield during repeated IVF.
    • These findings suggest that IVF protocols can be sustained over multiple cycles without an inherent decline in oocyte quantity, provided age is considered.