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Inclusion complex of fenbufen with beta-cyclodextrin
I Bratu1, J M Gavira-Vallejo, A Hernanz
1National R and D Institute of Isotopic and Molecular Technologies, PO Box 700, Cluj-Napoca, Romania. ibratu@s3.itim-cj.ro
Biopolymers
|March 3, 2004
Abstract:
An inclusion complex of fenbufen with beta-cyclodextrin (beta-CD) in aqueous solution was characterized by (1)H-NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (M(-1)) was calculated. The geometry of the inclusion complex was established based on MM(+) molecular mechanics calculations.