Related Experiment Video

Updated: Aug 26, 2026

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
09:21

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Published on: January 4, 2016

[On the bile acid receptor FXR]

Shuo Li1, Zhi-Wen Zhang, You-Fei Guan

  • 1Department of Physiology, Peking University Health Science Center, Beijing 100083.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|March 3, 2004
PubMed

Insights

Farnesoid X receptor (FXR) regulates bile acid and cholesterol. This review summarizes FXR

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Farnesoid X receptor (FXR) identified as a key bile acid receptor.
  • FXR plays a crucial role in regulating bile acid biosynthesis and cholesterol metabolism.
  • FXR is implicated in cardiovascular and liver diseases.

Purpose of the Study:

  • To review the discovery and biological roles of FXR.
  • To explore FXR's application in managing cardiovascular diseases.
  • To summarize FXR's involvement in bile acid and cholesterol homeostasis.

Main Methods:

  • Literature review of FXR research.
  • Analysis of studies on FXR's role in metabolism.
  • Synthesis of information on FXR's therapeutic potential.

Main Results:

  • FXR's discovery as a nuclear receptor activated by bile acids.
  • Elucidation of FXR's function in regulating genes involved in bile acid synthesis and transport.
  • Evidence supporting FXR's impact on lipid metabolism and cardiovascular health.

Conclusions:

  • FXR is a critical regulator of bile acid and cholesterol metabolism.
  • FXR represents a promising therapeutic target for metabolic and cardiovascular diseases.
  • Further research into FXR modulation could yield novel treatments.

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