Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sublingual misoprostol before first trimester abortion: a comparative study using two dose regimens.

N Vimala1, S Mittal, S Kumar

  • 1Department of Obstetrics & Gynaecology, AIIMS, New Delhi, India.

Indian Journal of Medical Sciences
|March 3, 2004
PubMed
Summary

For first-trimester pregnancy termination, 400 micrograms of sublingual misoprostol administered two hours before vacuum aspiration is optimal for cervical dilatation. Longer intervals do not improve dilation and increase side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endodontic retreatment practice trends among dental surgeons: A survey-based research.

Journal of conservative dentistry and endodontics·2024
Same author

Resection of Unresectable Stage IVB Thyroid Cancer Encasing the Carotid Artery.

The Indian journal of surgery·2016
Same author

An insight into dentin desensitizing agents--in vivo study.

Indian journal of dental research : official publication of Indian Society for Dental Research·2013
Same author

Protective potential of casein phosphopeptide amorphous calcium phosphate containing paste on enamel surfaces.

Journal of conservative dentistry : JCD·2013
Same author

Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2006
Same author

Placental site trophoblastic tumor originating in a tubal ectopic pregnancy.

European journal of obstetrics, gynecology, and reproductive biology·2006

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology

Background:

  • Preoperative cervical priming facilitates vacuum aspiration (VA) for first-trimester pregnancy termination.
  • Misoprostol, a prostaglandin E1 analogue, is effective for cervical dilatation prior to VA, offering advantages in stability, administration, and side effect profile compared to other prostaglandins.

Purpose of the Study:

  • To determine the optimal dosage and dosing interval of sublingually administered misoprostol for pre-abortion cervical dilatation.

Main Methods:

  • A prospective randomized study involved 120 pregnant women (6-11 weeks gestation) undergoing voluntary medical termination of pregnancy.
  • Participants were randomized to receive either 200 or 400 micrograms of sublingual misoprostol.
  • Vacuum aspiration was performed 2 or 3 hours post-administration, with cervical dilatation measured using Hegar's dilators. Blood loss and side effects were also assessed.

Related Experiment Videos

Main Results:

  • 71% of women in the 400 mcg group achieved ≥8 mm dilatation versus 33% in the 200 mcg group (Odds Ratio 95.8).
  • Mean baseline dilatation was significantly greater in the 400 mcg group (8.2 mm) compared to the 200 mcg group (6.0 mm) (P < 0.001).
  • The 400 mcg dose with a 2-hour interval was optimal; extending the interval to 3 hours showed no additional benefit but increased side effects like vaginal bleeding, abdominal pain, and shivering.

Conclusions:

  • Sublingual administration of 400 mcg misoprostol at least two hours prior to vacuum aspiration is effective for preoperative cervical dilatation in first-trimester pregnancy termination.
  • Increasing the misoprostol dosing interval beyond two hours does not provide additional advantages for cervical dilatation and may increase adverse effects.