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[Histological evaluation of the biocompatibility of PDLLA membranes]
1Department of Oral Medicine, Shanghai Second Medical University, Ninth People's Hospital, Shanghai 200011, China. Lxiaofeng99@hotmail.com
Objective:
To evaluate the histological response and biocompatibility of implanted domestic bio-degradable PDLLA membranes in vivo.
Methods:
The domestic biodegradable PDLLA membranes and non-degradable ePTFE membranes were in pairs placed subcutaneously in surgical incision made in the dorsum of rats. The tissue responses to these materials were observed histologically at 1, 2, 4, 8 and 12 weeks after placement.
Results:
The tissue responses of the two kinds of materials were similar to the non-specific reaction mainly infiltrated with lymphocytes, plasmocytes, macrophages, and foreign body giant cells. The polymorphonuclears and foreign body giant cells infiltrated round the ePTFE membranes existed for a relatively long period, in contrast to that of PDLLA membranes.
Conclusion:
Domestic PDLLA membranes with good biocompatibility will be adapted to making GTR into a single step procedure.
