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Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy.
Francisco Olán1, Margarita Portela, Carmen Navarro
1National Institute of Cardiology and National Institute of Respiratory Diseases, Mexico City, Mexico.
The Journal of Rheumatology
|March 3, 2004
Abstract:
Vascular endothelial growth factor (VEGF) is a cytokine overexpressed in hypoxic and malignant pathologies. VEGF induces vascular hyperplasia, new bone formation, and edema. These histological abnormalities characterize hypertrophic osteoarthropathy. We describe a case of pulmonary hypertrophic osteoarthropathy with high circulating VEGF levels. Removal of the lung tumor led to a dramatic disappearance of the skeletal abnormalities and to reduction of circulating VEGF levels. Histochemical studies of the excised tumor confirmed abnormal VEGF production.
