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[Plasma membrane remodelling and cell stimulation]
Maria Carmen Martínez1, Corinne Kunzelmann, Jean-Marie Freyssinet
1Institut d'Hématologie et d'Immunologie, Faculté de Médecine, Université Louis Pasteur, 4, rue Kirschleger, 67085 Strasbourg Cedex, France.
Medecine Sciences : M/S
|March 5, 2004
Summary
The plasma membrane is more than a barrier; it regulates cell communication and signaling. This review explores membrane plasticity and phospholipid asymmetry during cell activation.
Area of Science:
- Cell Biology
- Biochemistry
- Physiology
Context:
- The plasma membrane's role has evolved from a simple barrier to a dynamic regulator of cellular processes.
- It is crucial for cell-environment communication and intracellular signaling.
- Membrane structure changes facilitate the transfer of biological information between cells.
Purpose:
- To review recent advancements in understanding plasma membrane plasticity.
- To focus on intracellular signaling pathways regulating phospholipid asymmetry loss during cell activation.
- To briefly discuss the pathophysiological outcomes of microparticle shedding.
Summary:
- This review examines plasma membrane plasticity, emphasizing its role in cell communication and signaling.
- It details intracellular signaling pathways that control the loss of membrane phospholipid asymmetry in activated cells.
- The shedding of microparticles and microvesicles from membrane blebs and their pathological consequences are also discussed.
Impact:
- Provides insights into the dynamic nature of the plasma membrane.
- Highlights the importance of phospholipid asymmetry in cell activation and signaling.
- Offers a brief overview of the pathological implications of membrane blebbing and microparticle release.