Related Experiment Video

Updated: Aug 26, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies

Reade B Roberts1, Carlos L Arteaga, David W Threadgill

  • 1Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

Cancer Cell
|March 5, 2004
PubMed

Insights

Genetically engineered mouse models can predict side effects from targeted cancer therapies. These models also help identify genetic variations that may increase patient susceptibility to adverse drug reactions.

Area of Science:

  • Oncology
  • Pharmacology
  • Genetics

Background:

  • Personalized cancer treatments based on tumor profiling are advancing.
  • Molecule-targeted therapies offer precision but can cause unforeseen side effects.
  • Chronic treatment use may lead to degenerative toxicities missed in short trials.

Purpose of the Study:

  • To review and propose genetically engineered mouse models (GEMMs) for predicting targeted therapy toxicity.
  • To identify genetic variants predisposing patients to treatment side effects.

Main Methods:

  • Review of current literature on targeted cancer therapies and toxicity.
  • Proposal for the application of GEMMs in preclinical toxicity assessment.
  • Discussion of GEMMs for identifying individual susceptibility factors.

Main Results:

  • GEMMs can recapitulate specific genetic alterations found in human tumors.
  • GEMMs allow for controlled, long-term exposure to targeted agents.
  • GEMMs facilitate the study of off-target effects and emergent toxicities.

Conclusions:

  • Genetically engineered mouse models are crucial for predicting the toxicity of novel targeted cancer therapies.
  • GEMMs can aid in identifying patients at higher risk for adverse events due to specific genetic profiles.
  • Integrating GEMMs into drug development pipelines can enhance the safety and efficacy of personalized cancer medicine.

More Related Videos

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer11:31

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Published on: May 20, 2016

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...