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Updated: Aug 26, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Nitrosation of thiols and thioethers in the gas phase: a combined theoretical and experimental study
Pascal Gerbaux1, Pascale Wantier, Robert Flammang
1Organic Chemistry Laboratory, University of Mons-Hainaut, Mons, Belgium. pascal.gerbaux@umh.ac.be
Abstract:
Recent studies have demonstrated the biological importance of the interaction of nitric oxide with proteins such as cytochrome-c or hemoglobin. In particular, the possibility that the nitrosonium cation, NO(+), could reversibly bind to sulfide atom type was proposed. At pH values of biological relevance, nitrosation was proposed to occur through the action of NO(+) carriers such as nitrosothiols or nitrosamines. In this context, the gas phase chemistry of protonated nitrosothiols is studied in the present work by a combination of mass spectrometry and computational methods.
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