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Updated: Aug 26, 2026

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
Published on: December 3, 2020
Attachment of metal trications to peptides
Alexandre A Shvartsburg1, Richard C Jones
1Pacific Northwest National Laboratory, Richland, Washington 99352, USA. alexandre.shvartsburg@pnl.gov
Abstract:
Gas-phase complexes of triply charged metal ions with peptides may be readily produced using electrospray ionization, including for small peptides such as bradykinin and peptides with no basic residues such as insulin chain A. Attachment without charge-reduction is demonstrated for all trications studied: La(3+), Al(3+), Ga(3+), Fe(3+), V(3+), and Cr(3+). The intensities of adducts are often comparable to, or even exceed, those of protonated analogs in any charge state.
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