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Peroxisome proliferator-activated receptor alpha target genes
S Mandard1, M Müller, S Kersten
1Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 Wageningen, The Netherlands.
Cellular and Molecular Life Sciences : CMLS
|March 5, 2004
Summary
Peroxisome proliferator-activated receptors alpha (PPARα) regulate fatty acid metabolism and other pathways. This review details PPARα target genes involved in diverse biological processes.
Area of Science:
- Molecular Biology
- Biochemistry
- Genetics
Background:
- Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors mediating lipophilic compound effects.
- PPARs regulate gene transcription, influencing various metabolic and cellular processes.
Purpose of the Study:
- To review the role of PPARalpha (PPARα) in diverse biological pathways.
- To analyze known and putative PPARα target genes.
Main Methods:
- Literature review of PPARα involvement in biological pathways.
- Analysis of PPARα target genes.
Main Results:
- PPARα is involved in fatty acid oxidation (peroxisomal and mitochondrial).
- PPARα influences microsomal fatty acid hydroxylation, lipoprotein, bile, and amino acid metabolism.
- PPARα plays roles in glucose homeostasis, biotransformation, inflammation control, and hepato-carcinogenesis.
Conclusions:
- PPARα is a key regulator of numerous metabolic and cellular functions.
- Understanding PPARα target genes is crucial for comprehending its broad physiological impact.