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Accurate dose calibrator activity measurement of 90Y-ibritumomab tiuxetan
Jeffry A Siegel1, Brian E Zimmerman, Kory Kodimer
1Nuclear Physics Enterprises, Wellington, Florida 33414, USA. siegelja@aol.com
Unlabelled:
This investigation examined the accuracy of dose calibrator activity measurement of the beta-emitting radiopharmaceutical (90)Y-ibritumomab tiuxetan.
Methods:
Five different facilities independently measured (90)Y in a 10-mL syringe geometry with 30 dose calibrator models from 3 different manufacturers. The activities ranged from 81.4 MBq (2.2 mCi) to 1,406 MBq (38 mCi) over the volume range of 3-9 mL.
Results:
The mean dial settings for (90)Y measurement were 375, 51 x 10, and 897 x 100 for Atomlab, CRC, and Mark V dose calibrators, respectively. The maximum volume dependence was 0.28%/mL.
Conclusion:
This study demonstrated that when measuring all volumes of (90)Y-ibritumomab tiuxetan activity prescriptions, only a single dial setting for a given manufacturer's dose calibrator is required for accurate measurements. Volume corrections are not necessary. For best accuracy, an individually determined dial value should be used.
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