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Updated: Jul 12, 2026
Technique to Target Microinjection to the Developing Xenopus Kidney
Published on: May 3, 2016
Effects of microgravity and hypergravity on early development stages of Xeonopus laevis
1Institute of General Physiology and Biochemistry, University of Milan, Milan, Italy. angelamaria.rizzo@unimi.it
Abstract:
The aim of this work is to evaluate the development of X.l. in modified gravity conditions. The simulation of hyper and microgravity was performed utilizing: an hyperfuge, a Clinostat and later on a Random Positioning Machine (RPM, 3d Clinostat). The effect of hypergravity on embryos is significantly higher than that of microgravity; the exposure of embryos to 3xg for 3 days before and after hatch causes an activation of HSP-60 and HSP-70. Embryos exposed to 3xg during the first 3 days of development are very sensitive and show a retard of development, with a lower content of DNA, neutral glycolipids and gangliosides compared to controls.
