Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The caveolin proteins.

Terence M Williams1, Michael P Lisanti

  • 1Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

Genome Biology
|March 9, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the Role of Peroxisomes in Regulating Breast Cancer Stem Cell Mechanisms.

International journal of molecular sciences·2025
Same author

Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor-Positive Breast Cancer Cells.

The American journal of pathology·2025
Same author

ALDH<sup>High</sup> Breast Cancer Stem Cells Exhibit a Mesenchymal-Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities.

Cells·2025
Same author

High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo.

Cell death & disease·2024
Same author

Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration.

Aging·2024
Same author

In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods.

Cells·2024
Same journal

Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana.

Genome biology·2026
Same journal

UK Biobank whole-genome sequencing reveals robust contributions of rare variants to complex-trait heritability.

Genome biology·2026
Same journal

A one-week automated genome-wide optical pooled screen using OttoSeq.

Genome biology·2026
Same journal

Integrated lipidomic and transcriptomic profiling of the host response in human malaria.

Genome biology·2026
Same journal

Centromeric satellite expansion drives genome evolution in the snowy owl.

Genome biology·2026
Same journal

Mapping the landscape of allele-specific expression in porcine genomes.

Genome biology·2026
See all related articles

The caveolin gene family, including caveolin-1, -2, and -3, plays roles in cellular processes like transport and signaling. These proteins mark caveolae, essential plasma membrane invaginations found across various species.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The caveolin gene family comprises three members: caveolin-1, caveolin-2, and caveolin-3.
  • Caveolins are integral membrane proteins that serve as markers for caveolae, which are specialized plasma membrane invaginations.
  • While research has primarily focused on mammals, caveolins are conserved across vertebrates and found in species like Xenopus laevis and Caenorhabditis elegans.

Purpose of the Study:

  • To provide a comprehensive overview of the caveolin gene family.
  • To detail the structure, localization, and expression patterns of caveolin proteins.
  • To highlight the diverse cellular functions mediated by caveolins.

Main Methods:

  • Literature review and synthesis of existing research on caveolins.

Related Experiment Videos

  • Analysis of protein localization studies across different cellular compartments.
  • Examination of gene expression data and tissue-specific distribution.

    • Main Results:

    • Caveolins are localized to the plasma membrane, Golgi, endoplasmic reticulum, vesicles, and cytoplasm.
    • Caveolin-1 is highly expressed in terminally differentiated cells like adipocytes and endothelial cells.
    • Caveolin-2 coexpresses and colocalizes with Caveolin-1, requiring it for membrane targeting; Caveolin-3 is primarily found in muscle cells.

    Conclusions:

    • Caveolins are crucial for cellular functions including vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.
    • The distinct expression patterns and interactions of caveolin family members suggest specialized roles.
    • Understanding caveolin biology is essential for insights into various physiological and pathological processes.