Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Migraine aura: a knockin mouse with a knockout message.

Peter J Goadsby1

  • 1Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.

Neuron
|March 9, 2004
PubMed
Summary

Familial hemiplegic migraine is a brain disorder causing neurological symptoms. A new study shows a genetic mutation lowers the threshold for cortical spreading depression, explaining the severe migraine aura phenotype.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting dose-finding of monoclonal antibodies in migraine.

The journal of headache and pain·2023
Same author

Estimating treatment effects on health utility scores for patients living with migraine: a post hoc analysis of the DELIVER trial.

Expert review of pharmacoeconomics & outcomes research·2023
Same author

Migraine: from pathophysiology to treatment.

Journal of neurology·2023
Same author

Evaluating migraine with typical aura with neuroimaging.

Frontiers in human neuroscience·2023
Same author

Non-invasive neuromodulation of the cervical vagus nerve in rare primary headaches.

Frontiers in pain research (Lausanne, Switzerland)·2023
Same author

Effectiveness and safety profile of greater occipital nerve blockade in cluster headache: a systematic review.

Journal of neurology, neurosurgery, and psychiatry·2023

Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Migraine aura presents significant neurological symptoms in approximately 30% of patients.
  • Familial hemiplegic migraine (FHM) is a rare, inherited form of migraine with aura.
  • Understanding the pathophysiology of FHM is crucial for developing effective treatments.

Discussion:

  • This study investigates a mouse model with a knockin mutation linked to FHM.
  • The research provides evidence connecting a lowered threshold for cortical spreading depression (CSD) to the FHM phenotype.
  • CSD is a wave of altered neuronal activity that may underlie migraine aura.

Key Insights:

  • A specific genetic mutation associated with FHM lowers the brain's threshold for triggering CSD.
  • This reduced CSD threshold is implicated as a potential cause of the severe neurological symptoms observed in FHM.

Related Experiment Videos

  • The findings offer a mechanistic link between genetic predisposition and the clinical presentation of FHM.

    • Outlook:

    • Further research could explore therapeutic strategies targeting CSD in FHM patients.
    • This study may pave the way for novel diagnostic approaches for migraine disorders.
    • Investigating this genetic link could advance our understanding of broader neurological conditions involving CSD.