Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoregulatory T cells in autoimmunity.

Jose C Crispin1, Maria Ines Vargas, Jorge Alcocer-Varela

  • 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México 14000, Tlalpan D. F. Mexico City, Mexico.

Autoimmunity Reviews
|March 9, 2004
PubMed
Summary

Regulatory T cells (T(R)) play a crucial role in preventing autoimmune diseases. Dysregulation of these CD4(+)CD25(+) T cells can lead to organ-specific autoimmunity, highlighting their importance in immune homeostasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CAR T cells for systemic autoimmune diseases.

Autoimmunity reviews·2026
Same author

The transcription factor Helios restrains the anti-tumor capacity of CD8<sup>+</sup> T cells.

Cell reports·2025
Same author

Definition of clinical immunology around the globe.

Frontiers in immunology·2025
Same author

Immune complex deposition promotes NK cell accumulation in the kidney.

PloS one·2024
Same author

Impact on Fatality Rates and Years of Life Lost During the COVID-19 Pandemic: The Experience of the Mexican Public Health Incident Management Command.

Archives of medical research·2024
Same author

Sepsis Impairs IFN-γ Production in CD8 T Cells through Changes in Local Chromatin Landscape.

Journal of immunology (Baltimore, Md. : 1950)·2024

Area of Science:

  • Immunology
  • Autoimmunity

Background:

  • Regulatory T cells (T(R)), characterized as CD4(+)CD25(+) T cells, possess potent suppressive functions.
  • Alterations in T(R) cell populations are linked to the development of organ-specific autoimmune diseases in animal models.

Purpose of the Study:

  • To review current knowledge on the role of regulatory T cells in the pathogenesis of autoimmune diseases.
  • To explore the mechanisms and factors influencing T(R) cell function and survival.

Main Methods:

  • Literature review of studies on regulatory T cells and autoimmunity.
  • Discussion of cellular mechanisms including T cell receptor (TCR) stimulation, co-stimulation with IL-2, and cytokine involvement (IL-10, TGF-β, IL-4).

Main Results:

Related Experiment Videos

  • T(R) cells are anergic upon TCR stimulation alone but proliferate with IL-2 co-stimulation.
  • CD4(+)CD25(+) T cells suppress CD4(+)CD25(-) T cell proliferation by inhibiting IL-2 transcription.
  • IL-2, IL-2R components, and costimulatory molecules are essential for T(R) cell survival and expansion.
  • Cytokines like IL-10, TGF-β, and IL-4 are implicated in the in vivo function of regulatory cells in autoimmunity.

    • Conclusions:

    • Regulatory T cells are critical for maintaining immune tolerance and preventing autoimmunity.
    • While their role in animal models is established, the function of T(R) cells in human autoimmune diseases requires further investigation.
    • Understanding T(R) cell biology is crucial for developing novel therapeutic strategies for autoimmune disorders.