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Related Experiment Videos

Cerebral perfusion assessment by bolus tracking using hyperpolarized 13C.

E Johansson1, S Månsson, R Wirestam

  • 1Department of Radiation Physics, Lund University Hospital, Lund, Sweden. edvin.johansson@radfys.lu.se

Magnetic Resonance in Medicine
|March 9, 2004
PubMed
Summary

This study used hyperpolarized 13C MRI to assess cerebral perfusion in rats, avoiding issues with traditional contrast agents. The method shows promise for mapping cerebral blood flow (CBF), but requires compensation for tracer depolarization to accurately quantify CBV and MTT.

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Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Traditional dynamic susceptibility contrast (DSC) MRI faces challenges in accurately quantifying cerebral perfusion parameters.
  • Dynamic nuclear polarization (DNP) enables hyperpolarization of 13C tracers, offering a direct signal source for MRI.
  • Assessing cerebral perfusion is crucial for understanding various neurological conditions.

Purpose of the Study:

  • To evaluate the utility of DNP-enhanced 13C MRI for assessing cerebral perfusion in a rat model.
  • To investigate the impact of tracer depolarization on quantitative perfusion measurements.
  • To develop and test methods for compensating depolarization effects in 13C MRI perfusion mapping.

Main Methods:

  • Intravenous injection of a DNP-hyperpolarized 13C-labeled cyclopropane derivative in rats.

Related Experiment Videos

  • Acquisition of 13C MRI data to generate maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT).
  • Application of modified bolus-tracking theory and numerical simulations to investigate depolarization compensation strategies.

    • Main Results:

    • MTT was determined to be 2.8 +/- 0.8 sec.
    • Arterial partial-volume effects limited absolute quantification of CBF and CBV.
    • Depolarization significantly underestimated CBV and MTT, particularly at longer MTTs or higher depolarization rates.
    • Compensation methods were investigated to correct for depolarization effects.

    Conclusions:

    • DNP-enhanced 13C MRI is a viable technique for cerebral perfusion assessment, avoiding DSC limitations.
    • Accurate quantification of CBV and MTT requires accounting for tracer depolarization.
    • Modified bolus-tracking theory with known depolarization rates allows for compensation, improving quantitative accuracy.