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Kawasaki disease in Thai infants compared with older children

Rekwan Sittiwangkul1, Yupada Pongprot, Wanathorn Thongsongkrit

  • 1Division of Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. rsittiwa@med.cmu.ac.th

Annals of Tropical Paediatrics
|March 10, 2004
PubMed

Insights

Infants with Kawasaki disease (KD) present with more non-classical symptoms and delayed treatment, increasing their risk for coronary artery abnormalities (CAA). Early recognition and intervention are crucial for better outcomes in infant KD patients.

Area of Science:

  • Pediatrics
  • Cardiology
  • Infectious Diseases

Background:

  • Kawasaki disease (KD) poses a significant risk of coronary artery abnormalities (CAA) in infants.
  • Understanding infant-specific clinical features is vital for timely diagnosis and management.

Purpose of the Study:

  • To evaluate clinical features of KD in infants.
  • To compare infant KD cases with older children.
  • To identify risk factors for CAA in infants with KD.

Main Methods:

  • Retrospective study of 51 children with KD admitted to a tertiary care hospital (1993-2003).
  • Analysis of clinical manifestations, treatment delays, and CAA development.
  • Comparison between infants (<1 year) and older children.

Main Results:

  • Infants (43% of cohort) showed more non-classical symptoms like diarrhea (68% vs 38%).
  • Infants received intravenous immunoglobulin (IVIG) treatment 2 days later on average.
  • Predictors of CAA in infants included IVIG resistance and prolonged fever duration.

Conclusions:

  • Infants with KD often present with atypical symptoms, potentially delaying diagnosis and treatment.
  • Delayed treatment and atypical presentations in infants are linked to increased risk of CAA.
  • Further research into early diagnostic markers and treatment strategies for infant KD is warranted.

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