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Use of a quantitative gene expression assay based on micro-array techniques and a mathematical model for the

D P Wilson1, S Mathews, C Wan

  • 1School of Mathematical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane Qld 4001, Australia. d.wilson@fsc.qut.edu.au

Bulletin of Mathematical Biology
|March 10, 2004
PubMed

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...